Here we explored the potential of systemic administration of pluripotent bone marrow-derived mesenchymal stem cells (MSCs) to rescue vision and associated vascular pathology in the Royal College Surgeons (RCS) rat, a well-established animal model for RP.
He et al. (2007) [ 19] profiled miRNA expression in skeletal muscle in the Goto-Kakizaki (GK) rat, a well-characterized model of T2D, and compared it to normal Wistar rats; miR-29 paralogs were found to be over-expressed in the GK rat.
We firstly used the chronic unpredictable stress (CUS) procedure of rats, a well validated stress-related animal model of depression, to further determine the antidepressant-like of YL-IPA08.
The ovariectomized (OVX) rat is a well established model for osteoporosis research.
The Dahl salt-sensitive (DSS) rat is a well established model for salt-induced hypertension and renal failure.
In the present study we employed the spontaneously hypertensive rat (SHR), a well validated genetically determined ADHD model [ 35- 37], to examine whether increased access to n-3 PUFAs during pregnancy and development may modulate behavioural symptoms and brain neurotransmitter metabolism [ 38].
To test this hypothesis, we performed an in vitro patch-clamp study on WAG/Rij rats, a well-validated genetic model of AE, in order to assess dampened GABAergic synaptic transmission in the IGL expressed as a lower IPSC amplitude and reduced sIPSC frequency.
Results In this study, the authors used adriamycin-injected rats, a well-established model in which the animals develop proteinuria 6 weeks post-injection.
In our previous studies, we used the carotid artery balloon injury model in obese Zucker rats, a well-established model of type II diabetes mellitus (T2DM) [ 22], as well as lean Zucker rats, to investigate the vascular response to balloon injury in diabetes [ 23- 25].
Uchida et al. used Fischer 344 (F344) rats, a well-known stress-hyperresponsive model, and showed that this strain, upon a 14-day repeat restrain stress, had increased levels of miR-18a and decreased GR protein expression in the PVN, compared with control Sprague Dawley (SD) rats [ 66].
