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This suggests that the receptor affinity for minipig might be close to the human value while in mouse and rat a significant loss of binding was observed.
Furthermore, after 2 weeks of BDL in the rat, a significant peribiliary plexus proliferation is produced that is drained by small venules in both the portal vein branches and hepatic sinusoids [ 59].
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In diabetic rats, a significant reduction in blood glucose levels was observed 1 h after a single oral administration (p < 0.001).
In normal rats, a significant reduction in blood glucose levels 2 h was observed after a single oral administration (p < 0.001).
Conversely, in antisense-, but not missense-treated rats, a significant attenuation of MDMA-induced neurotoxicity was observed only in the ipsilateral striatum.
In rats a significant increase of the copper biliary excretion is produced by valproic acid administration, however, a conclusive study on the possible appearance of copper deficiency in humans during treatment with this drug has still not been carried out.
In control rats, a significant increase in HR was sustained after the second exchange.
In arthritic rats, a significant depletion of proteoglycan synthesis was observed from 1 to 3 days after the antigenic challenge.
Comparing each single tissue between ZL and ZDF rats a significant higher expression level was only found in the kidney fat for lean animals.
Besides rats, a significant decrease in AR expression occurs in porcine myometrium 3 weeks prior to labour (Slomczynska et al., 2008).
After administration of arecoline to diabetic rats, a significant increase (P < 0.01) in liver glycogen content as compared to diabetic control group was observed.
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