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For example, megalin expression was reduced in the Ren2 rat, a model used for studying hypertension and metabolic syndrome [66].
We first used the ZDF fa/fa rat, a model for type 2 diabetes with impaired functional β-cell mass [16].
Although, OX1R is present in the pancreatic islets of GK rats, a model of type 2 diabetes, the degree of co-localization with GLU was minimal compared to that STZ-induced diabetic rat (a model of type 1 diabetes).
We present evidence for an alternative strategy aimed at preventing the secondary loss of cones, the most crucial photoreceptors for vision, by transplanting normal photoreceptors cells into the eye of the P23H rat, a model of dominant retinitis pigmentosa.
Furthermore we analyse their functionality in vitro, and in vivo after transplantation of iPS-RPE into the dystrophic RCS rat: a model of retinal dystrophy where the primary defect, originating in RPE cells [26], leads to blindness as a consequence of rod and cone photoreceptor degeneration[27] [29].
Microglial cytorrhexis occurs in the SOD1G93A rat, a model of amyotrophic lateral sclerosis [ 8].
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These results hold true for control rats as well as streptozocin (STZ) rats, a model for type 1 diabetes mellitus.
Our rat model is a model of acute encephalitis thus giving the possibility to investigate the early mechanisms underlying disease.
Animal studies did not report any survival benefit either with atropine in a rat model, glucagon in a dog model, or levosimendan in a rat model.
However, he adds, "this is a rat model, not a primate model".
Sucrose consumption is a rat model of an anhedonialike state [ 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com