The putative miR-187 binding site is conserved from human to rat so a decrease in Hipk3 expression was expected.
We hypothesized that, like withdrawal from other drugs of abuse, the cessation of PCP treatment will produce in rats a decrease in brain reward function that will reflect a deficit in experiencing pleasure.
Similar to stressed rats, cort-injected rats showed a decrease in the percentage of new neurons, and an increase in the percentage of new oligodendrocytes, relative to controls (Figure 1e).
An early biochemical study based on the measurements of tissue concentrations of 5-HT and 5-HIAA in the rat found a decrease in 5-HT metabolism (5-HIAA to 5-HT ratio) in the limbic forebrain 20 min after galanin administration (Fuxe et al. 1988a).
Any rat showing a decrease in mean grip score is at increased probability of DCS.
After two days of immobilisation of rat hindlimbs, a decrease in the respiration speed (by 37%) was determined in the subsarcolemmal mitochondria extracted from the m.
Upon central administration of AST3-88 into rats, a decreased food intake response was observed.
In rats, a decreased intracellular cholesterol content and simultaneous increase in LDL-C levels have been observed under fasting conditions [ 4, 42, 44, 45].
In rats, a decreased serum level of free radical metabolising/scavenging enzymes and glucose has been observed after oral administration, suggesting a deranged systemic capacity to handle oxidative radicals after khat use (Al-Qirim et al, 2002).
In rats, a decreased serum 17β-estradiol (E2) and aromatase mRNA level in Leydig cells was interpreted to play a role in inhibited testicular steroidogenesis by BPA (Akingbemi et al. 2004).
