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This study recorded a 6% rash rate.
On the other hand, the skin rash rate was reported quite similar in Chinese patients and western patients that administered solvent-based paclitaxel [ 12] (P > 0.05) (See Table 2).
Similar rash rate at 26% was reported in another phase III study that compared nab-paclitaxel with Cremophor-EL-containing paclitaxel in Chinese MBC patients [ 10], similar to the rate reported in our study (P > 0.05, see Table 2).
The similarity in the skin rash rate among the Chinese population and a obviously higher skin rash incidence in comparison with western patients suggested a potential problem——a different mechanism of action may play a role in this new agent for breast cancer.
Similar(56)
IOG supervised analyses of skin biopsies and participated in interpretation of rash rating results.
CTCAE and EIR scales were compared by plotting worst rash rating at any point in the first month of treatment.
A comparison of the worst rash rating for each patient by each scale shows the EIR scale to distribute the typical range of rash more broadly than CTCAE.
Given the small sample and the absence of any association between rash and treatment outcome, a test for interaction between rash rating and serum proteomic predictor was not performed.
The randomization and 2-week run-in design of the trial enabled concurrent analysis of rash rating and the serum assay as candidate predictive markers for cetuximab therapy in NSCLC.
30 The third study reported a 5% rash incidence rate.
23 29 30 Two of these each reported a rash incidence rate of 7%, 23 30 while one of these escalated the dose rapidly over 6 weeks.
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CEO of Professional Science Editing for Scientists @ prosciediting.com