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In anti-MJ, heliotrope rash (P = 0.01) and calcinosis (P = 0.09) were more frequent.
The most robust clinical predictors of time to progression (TTP) were best response and rash (p < 0.0001).
Response to cetuximab was seen in 12.5% of patients with no rash versus 40% of patients who developed some degree of rash (p = 0.019).
Elderly patients had co-morbid conditions more frequently (P < 0.0001) and more frequently lacked fever (P = 0.0625), neck stiffness (P < 0.0001) and skin rash (P < 0.0001), but had an altered level of consciousness more often (P < 0.0001).
In anti-MJ patients, heliotrope rash (P = 0.01) and calcinosis (P = 0.09) were common, but none of them had heart involvement (0% vs 13%), interstitial lung disease (ILD) (0% vs 33%, P = 0.048), or malignancy (0% vs 8%).
All toxicities were associated with a significant decline in utility compared to stable disease with no toxicity, ranging from -0.03248 (rash) (p = 0.007) to -0.09002 (febrile neutropenia) (p = 0.0001).
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These analyses showed that the magnitude of association was strongest in cutaneous DLE (P-value ≥3.7×10−11; uncorrected P-values are reported), followed by SLE patients with discoid rash (P-value ≥3.9×10−9) and all SLE patients together (P-value ≥8.2×10−6) (Table 3).
Six (7.4%) patients in group A developed NVP-related skin rashes (P = 0.096).
There was a significant difference among the groups in the prevalence of skin rashes (p = 0.016).
Typical possible side effects from ART such as rash (χ2 =.09, P >.05), nausea (χ2 =.11, P >.05) and vomiting (χ2 = 1.21, P >.05) [ 13] did not differ significantly between patients on ART and not on ART.
HIV seropositivity was also significantly associated with cough, vomiting, lethargy/altered consciousness, skin rash and hepatomegaly (p value < 0.05 for all parameters).
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