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Skin rash, grade 2 or lower, was the most common adverse event, seen in 67% of patients.
Reasons for this included rash grade 3 (n = 4), rash grade 2 (n = 3), diarrhoea grade 3 (n = 1), and stomatitis grade 3 (n = 1).
Tolerability was good, with skin rash (grade 2), myalgia (grade 1) and slight vision impairment.
Cetuximab associated acneiform rash grade 3 was observed in 7% of the RIT patients.
Additionally, the subgroup analyses showed that patients given cetuximab who developed prominent cetuximab-induced acneiform rash (grade 2 4) had better overall survival compared with patients given cetuximab who developed a mild or not rash (grade 0 1).
Gefitinib was well tolerated, with the adverse events comprising skin rash (grade 2) and myalgia (grade 1).
Similar(38)
In this analysis we included patients with all rash grades, regardless of expected relationship with study treatment.
A semi-structured diary was provided to all mothers; this included a Diaper Area Rash grading scale [ 29, 30] to aid the process.
As known for tyrosine kinase inhibitors (TKI), the most frequent adverse events were any grade of rash (69.3% of the patients) and diarrhoea (41.3%), mostly mild or moderate (rash grades 1-2: 39 patients (52.0%), diarrhoea grades 1-2: 23 (30.6%)).
Referring to skin toxicity, patients without a rash had a median OS of 8 months, those with a mild rash (grades 1-2) had a median OS of 9 months, and in cases of severe rash (grades 3-4), the median OS was 7 months (P = 0.217).
14 While in patients without skin rash no objective response occurred, patients with increasing rash grades had responses ranging from 7.2% in mild rash up to 20% in severe skin toxicity.
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