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Exact(7)
Nimotuzumab (h-R3) has demonstrated clinical benefit without rash development in several clinical trials.
At the time of our original report, 9 previous phase III NSCLC clinical trials suggested a relationship between rash development and improved survival with TKI treatment.
A landmark analysis was performed to examine the association among PFS, OS and rash development by C1D8 (after 21 days of cetuximab therapy as in Gatzemeier, et al).
A dose-response relationship or differences in gene expression and immune response that simultaneously affect rash development and tumour response may underpin this (Amador et al, 2004; Guttman-Yassky et al, 2010).
The inclusion criteria for randomisation were completion of the run-in period: without evidence of disease progression (PD); without grade ⩾2 rash development; or without development of toxicity leading to dose adjustments <75% of the full chemotherapy dose.
We administered intramuscular benzathine penicillin 7.2MU, as three doses for 2.4MU each with a week apart, but the recurrence of skin lesions and new skin rash development with rise of nontreponemal titers were indicative of treatment failure.
Similar(52)
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Madinaty is just one of a rash of desert developments taking shape on Cairo's sandy fringes, where signature Greg Norman golf courses sprout from some of the most arid land imaginable and Zaha Hadid-designed office blocks are winched skyward at addresses that can be expressed only in kilometre distance-markers.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com