Sentence examples for ras figure from inspiring English sources

Importantly, inducing cellular differentiation by withdrawal of 4-hydroxy-tamoxifen and subsequent inactivation of the MLL-ENL-ER chimeric protein did not elevate checkpoint activation in the absence of oncogenic RAS (Figure S8), suggesting that the effects of oncogenic Ras on checkpoint activity are upstream and independent of its effects on cellular differentiation.

However spectra were characterized by a high variability of the intensity and by a worsening in the definition of the absorption bands as it can be evinced comparing the spectrum reported in Figure 1 with a reference spectrum of a more concentrated solution of AO7 (10−3 M) acquired in RAS (Figure 1c).

For instance, parts of the wingless (Wnt) signaling pathway, including the three main components of the 'ß-catenin destruction complex' [50], or activators and effectors of Ras (Figure 2B) [49].

Immunoblots confirmed that Ras cells expressed elevated levels of the Ha-Ras protein and displayed activation of Ras proteins as determined by binding to a GST-Raf protein and phosphorylation of Erk, a downstream effector of Ras (Figure 1B).

Interestingly, the PI3Kγ K251E mutant, which fails to bind to Ras [22] and hence to translocate to the endosome via activated Ras (Figure S1A, B), was unable to display a compensatory effect, unlike its wild-type counterpart (Figure 1A), while the expression levels were shown to be comparable by immunoblotting (Figure S1C).

Rosmarinic acid (RA, Figure 1) has been proven to be the main biological polyphenolic compound found in the stems, leaves and seeds of P. frutescens[8 10].

Our results confirmed the lack of H- and N-Ras isoforms, the presence of K-Ras4A distributed along the plasma membrane and the expression of K-Ras4B in plasma membrane and nuclei; these results confirm that the pattern of expression observed in mesangial and fibroblast nuclei supposedly corresponded to K-Ras (Figure 2).

Activated R-Ras did not co-immunoprecipitate with RGS14 in the absence of any of the three Raf kinases (Figure 5A); however, in the presence of the three Raf kinases, we observed weak interactions with R-Ras (Figure 5A) that were comparable to the preference of R-Ras for each of the three Raf isoforms (data not shown).

Interactions were observed with both Rap2A and Rap2B, and this binding appeared to be mediated by the first RBD in the tandem array; however, in contrast to the interaction with H-Ras (Figure 1A), the interaction was independent of the nucleotide state of Rap2A/2B (Figure 1B and 1C).

No multiple-nuclear TRAP positive cells were found in the presence of 4 nM RA (Figure 1C).

The transcription rate was further enhanced when nuclei were exposed to a combination of BU and RA (Figure 7).