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As for the bigger, badder bolides, the team extrapolated between the energy ranges of the 300 airbursts and those of the far rarer impacts.
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Given this situation, for a quantitative trait such as CRP, it may be more efficient to re-sequence individuals at the extreme low and high end of the distribution in the search for rarer SNPs that impact the phenotype of interest (Cohen et al. 2005; Cohen et al. 2004).
Our sample was too small to assess the impact of rarer conditions on survival, or to assess the impact of multiple combinations of specific conditions.
They are not powerful enough to detect signals from common variants with low impact, nor extensive enough to capture rarer variants with high impact.
For one, stories like mine will become rarer and rarer.
Therefore restricting health investigations to only a small number of scenarios has the potential for overlooking a rarer combination with strong impact on health [ 1].
Population structure exists in SNP-allele frequencies[ 43] and as observed by the results of this study, exclusion of rarer SNPs has an impact on the frequency of haplotypes that are observed.
Large impacts are much rarer and likely to be much more ancient.
Beyond common variants with rather weak effects as the above polymorphisms, the same five loci may also harbor rarer variants with a stronger impact on risk (mutations).
Vascular thromboembolic event can have lethal consequences and, although rarer in early-stage disease, the impact is greater in such patients.
The results indicate that efforts at conserving rarer species seem to be having an impact but may be too narrow an approach, possibly at the expense of more common species.
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CEO of Professional Science Editing for Scientists @ prosciediting.com