"We're one of the rare regions in the world that has the right soil and cold enough winters for the grapes to freeze," said Ben Nicks, a sales associate for Stratus Vineyards in Niagara-on-the-Lake.
It is also worth noting that rare, region-specific polymorphic variants may not be listed on public databases.
Although there were rare regions of normal triads, the majority did not resemble the native structure but were instead characterized by disorganized and swollen membrane structures.
The second cluster was composed of 16 cases (41%) harbouring rare regions of amplification, but whole-arm copy number alterations such as 8p−/8q+/16p−/16q+, hereinafter called the "Sawtooth/8/16" subset [ 37].
We determined that while high-frequency biallelic gene inactivation under model 1 is rare, regions of LOH (particularly copy-number neutral LOH) are enriched for deleterious mutations and increased promoter methylation, while copy-number loss LOH regions are likely to contain under-expressed genes suggestive of haploinsufficiency.
Non-random patterns of DNA marker distribution were observed, with some clear marker-dense regions and some marker-rare regions.
Accumulation of CRBP-1 in leiomyosarcoma likely supports the conversion of retinol into RA and its biological effects through RAREs induction, which influence the expression of many genes through the interaction with RAREs regions, inducing the increase of CRBP-1 expression in epithelioid SMCs as well as fibroblasts [ 29].
Although we could not show consistent binding of a retinoic acid receptor to the RARE containing region, several lines of evidence suggest that retinoid receptors target this or perhaps a more distal Akap12β promoter region.
The rare coding region variant rs36027551 (DPYS c.541C>T, p.Arg181Trp) was polymorphic but was not significantly associated with toxicity (5 carriers observed; 1 carrier experienced toxicity; P=1.00).
Conversely, GcvB protected SroC from T1 attack at G84, located in a rare accessible region at the tip of SL2 in the otherwise tightly folded SroC RNA.
For common, relatively common and rare CNV regions, we looked into the association of these regions and the flanking regions (up to 10 000 bp from the CNV boundaries) with sequence features: segmental duplications, genes and repetitive elements (Table 4).
