No available treatments slow or halt progression of multiple system atrophy, which is a rare, progressive, fatal neurological disorder.
Sontag S, Schnell T, Chejfec G, Metz A, Sonnenberg A. Abstract: The benign natural history of GERD: 20 years with rare serious progression.
In rare cases, progression of PA I to more malignant astrocytomas has been observed [ 9].
In the present data, the EANm responses were elicited by rare chord progressions, which is consistent with previous studies [3], [13], [22].
Reports of SMAD4 expression in prostate and other cancers are complex and variable, although mutation of the SMAD4 gene appears rare during PCa progression [ 54].
A rare form of progression in myeloma under therapy is leptomeningeal spread within the central nervous system, reported in 18 out of a series of 1856 patients [ 62].
However, complete responses are rare and disease progression is usually inevitable, and there is no consensus on the true impact of chemotherapy on survival and quality of life in patients with metastatic breast cancer (Bernard-Marty et al. 2004).
An exception to this scenario is the patient with lower limb symptoms due to lumbar canal stenosis at rest that can occur in severe cases and may indicate the rare but possible progression to paraplegia.
We did not observe a decrease in the already-rare prevalence or progression of cervical myelopathy over time.
This means that doctors know far less about the progression of rare diseases — and, because there are so few cases, they are often misdiagnosed.
