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The lack of readily available, patient-derived materials for molecular genetic testing of many heterozygous or rare disorders creates a major impediment for laboratory proficiency and quality control procedures.
Sample availability is, however, a limiting factor and the main impediment to progress of research in rare diseases, resulting in a remarkable lack of attempts to apply protein profiling approaches in the quest for protein markers in rare diseases.
Today, explicit discussions of homesickness are rare, for the emotion is typically regarded as an embarrassing impediment to individual progress and prosperity.
As haploinsufficiency is relatively rare [ 10], reduced copy number is not by itself an overwhelming impediment to large scale loss, as is evident from analysis of surviving duplicates in the Arabidopsis, rice, teleost, and yeast genomes [ 9, 11- 13].
Outside of New York, such impediments to homeownership are largely unheard of, because co-ops are so rare.
One impediment to family-based sequencing, however, is the fact that, with few exceptions, the statistics used to study rare variants were traditionally designed for use with population-based data.
The slight speech impediment.
Facts can become an impediment.
That impediment is the House of Representatives.
Parents are an impediment.
Time is the impediment".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com