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Most drug studies are not designed to assess rare effects, but as more drugs are sold to huge numbers of people who often take them for years, the question has become increasingly pressing.
"I'm mainly concerned with the NYPD's message and the media, because what they're talking about are rare effects and they're talking about them as if they occur to all users," Palamar.
Lack of theoretical knowledge also includes rare effects of opioids such as opioid-induced hyperalgesia [ 11].
Reasons for these conflicting results are unclear and may be due to our limited power to detect rare effects (Caucasians: MAF=0.02 vs African Americans: MAF=0.38).
Human chamber studies are limited with regard to assessing chronic effects, rare effects, or effects from long-duration exposures but are powerful in assessing acute, reversible effects from short-duration exposures in humans.
However, there are also limitations to primary data collection of a large prospective cohort; it is time- and resource-consuming, and recruitment of a sufficiently large sample size to allow the study of rare effects of MPH may be difficult.
Similar(51)
"It's in the absence of disease that this rare effect looms large".
And Mr. Owens achieved that rare effect: making his collection look avant garde and chic at the same time.
Even if true, this was a rare effect in our study, that was much smaller than published previously.
This is a rare effect and has not been known for a long time, so it is understandable that many pharmacists are indeed unaware of this adverse effect.
This is an extremely rare effect and there is evidence that the hepatic effect may be reversible when the drug is withdrawn.
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CEO of Professional Science Editing for Scientists @ prosciediting.com