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The rare conversion was the difference in a 29-28 win over the Atlanta Falcons.
When the N2B27 medium supplemented with small molecules was used at stage 2 to support reprogramming, only rare conversion of piPSCs to human ESC-like iPSCs could be observed, suggesting that the transgene expression during expansion in mTeSR1 was insufficient to reactivate the expression of the endogenous pluripotent genes in most piPSCs.
Notably, however, a single rare conversion event (e.g., from 11,18 to 11,11) could have a disproportionate impact on diversity because it would be equivalent to many single-step mutations.
Nevertheless, the publication of a series of papers showing rare conversion of a given cell type into another unrelated cell raised the possibility of using any unaffected tissue to create at will new cells to replace a different failing tissue or organ.
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Rare conversions between the silent and active states confer a quasi-stable pattern of epigenetically controlled gene expression in the vicinity of the telomeres [ 53].
Hirohito of Japan in 1945 was a rare exception – conversion from at least nominal absolutism and complicity in war crimes, to strict constitutionalism.
Novel combinations of genetic variation that differ greatly from the original sequence can result from the transfer of genetic variation between paralogous genes by rare gene conversion events.
When coupled with rare gene conversion events of divergent regions, this pattern can result in the formation of novel proteins differing substantially from either original protein.
Although very rare, gene conversion, recombination events, and reduction in full mutation to premutated or even normal alleles have been described, and have to be considered in an indirect diagnosis.
The combination of these islands of genetic divergence between paralogs with rare gene conversion events has the ability to construct radically different haplotypes from the combination of variation in both paralogs (as has happened in the SD and LJS GOT1p2 gene).
It was his first of the season and a rare power-play conversion for the Isles.
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