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Acute effects occur in rapidly renewing tissues, such as the linings of the oral cavity, the pharynx, the intestine, the urinary bladder, and the vagina.
Self-renewal is essential for multicellular organisms but carries the risk of somatic mutations that can lead to cancer, which is particularly critical for rapidly renewing tissues in a highly mutagenic environment such as the intestinal epithelium.
The intestinal epithelium represents the most rapidly renewing tissue in mammals [1].
Cell proliferation in all rapidly renewing mammalian tissues follows a circadian rhythm that is often disrupted in advanced-stage tumors.
Important differences between these other organ systems and the intestine is that the intestinal epithelium is a rapidly renewing, highly proliferative tissue that dynamically responds to its microenvironment.
A defining characteristic of the human intestinal epithelium is that it is the most rapidly renewing tissue in the body.
Similar(49)
The relationship between broad antimitotic activity and leukopenia is strong, given that granulocytes are rapidly renewed.
Only with the most severe genotypes would the rapidly renewed rods accumulate enough A2E to cause primary (i.e. not secondary to RPE loss) rod photoreceptor death.
In the case of rapidly renewed cells (intestine, skin) this residence time is the same as that of the whole cell, whereas in stationary cells it reflects the well-known specific renewal rate of protein within such cells [ 33].
The intestinal epithelium continually self-renews and can rapidly regenerate after damage.
The company was still growing rapidly, churn rates were down, and customers were actually renewing for additional paid plans, all leading to a healthy, fast-growing top line.
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