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Consequently, the drug can deeply penetrate into the plasma membrane, and rapidly impair selected enzymic activities leading to cell death.
In contrast, it has also been reported that Aβ rapidly impair mitochondrial transport without affecting mitochondrial function or the cytoskeleton in hippocampal neurons [42].
Owing to the fact that telomere uncapping can be achieved independently of telomere length, it emerges as a more universal way to rapidly impair the growth of dividing cells.
We have addressed whether induction of telomere dysfunction independently of telomere length by targeting a shelterin component could be applied as a more universal way to rapidly impair the growth of dividing cells.
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Inflammation rapidly impairs mood and cognition and, when severe, can appear indistinguishable from major depression.
Though clinically effective, IFN-α rapidly impairs mood, motivation and cognition, effects that can appear indistinguishable from major depression and provide powerful empirical support for the inflammation theory of depression.
Their results suggest that postprandial hyperglycemia rapidly impairs endothelial function through an increase in hyperglycemia-induced oxidative stress.
In addition, metabolic activity of the 5637 cells was rapidly impaired, and cell cycle arrest was induced at 1-3% cis-UCA.
We can thus speculate that the ability of the cells to detect the stiff matrix they are normally seeded on has become rapidly impaired.
In addition, metabolic activity of the 5637 cells is rapidly impaired, and the cells arrest in cell cycle in response to cis-UCA.
Interestingly, we found that integrin-mediated adhesion to the extracellular matrix was rapidly impaired in endothelial cells treated with Uncl-Sema3E; thereby, focal adhesions were disassembled and the actin cytoskeleton rearranged leading to the typical 'collapsed' phenotype.
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