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Neither phenotypic nor genotypic (16S ribosomal DNA sequence analysis) techniques can provide sufficient resolutions for accurately and rapidly identification of these species.
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In contrast to the rapidly expanding identification of individual lncRNAs, mechanistic characterization has lagged behind.
While the interpretation of protein altering differences has progressed rapidly, the identification of cis-regulatory modifying mutations remains a challenge.
Meanwhile, clinicians and hospitals should continue to dedicate time and resources to establish systems to identify these patients early and begin treatment rapidly after identification.
The advancement in our knowledge on emerging contaminants has been the result of the appearance of highly sensitive and powerful analytical instrumentation that rapidly developed, allowing identification and trace quantification of unknown contaminants in complex environmental matrices.
Typically, toxins evolve rapidly hampering the identification of these proteins by sequence analysis.
Such a strategy could rapidly allow the identification of a large number of causal variants if the association analysis was performed in mixed breed populations.
Early adoption of the Affymetrix technology by two groups rapidly led to identification of new players involved in Th1 and Th2 differentiation [ 10 14].
Advances in integrating genotypic and phenotypic data are leading rapidly to the identification of favorable and unfavorable alleles for particular markers (13, 14).
However, in the last 15 years, the tubulin superfamily expanded rapidly with the identification of further eukaryotic tubulin subfamilies (δ to κ), which were reported to be restricted to certain lineages or species.
With the sequencing of the human genome completed and with mRNA/cDNA identification rapidly progressing, many potential novel genes have been discovered and attention has turned to the function and structure of the predicted proteins [ 1- 4].
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