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ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the Golgi.
Biodistribution studies using radiolabeled naked siRNAs [44], [45] showed that siRNAs rapidly exit the blood compartment and enter into various tissues.
A subset of cellular and viral proteins that rapidly exit the ER employ either di-hydrophobic [7], di-basic [8] or di-acidic [9], [10] ER export signals that mediate their specific uptake into COPII vesicles by direct interaction with either Sec24 or Sar1 at ERES.
This implies that this NTR-species can rapidly exit the particle despite its very high partition coefficient.
It has always been assumed that sporozoites rapidly exit the injection site, making their interactions with the host at this site, brief and difficult to study.
We find that cells rapidly exit the co-expression state towards one of two mutually exclusive states, i.e. the system is bistable.
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The earthworms exhibited a marked response with a short latency specifically, many worms rapidly exited to the soil surface and attempted to exit the area, often by crawling over the container walls.
The escape response consists of rapidly exiting the soil, which prevents pursuit by the mole, and allows efficient movement away from the mole for subsequent burrowing at a more distant location.
The results show that the earthworms from the National Forest (Diplocardia) respond to moles by rapidly exiting the soil to flee across the surface and suggest that humans have unknowingly learned to mimic the vibrations caused by a digging mole to collect bait.
Here it is shown that a population of eastern American moles (Scalopus aquaticus) inhabits the area where worms are collected and that earthworms have a pronounced escape response from moles consisting of rapidly exiting their burrows to flee across the soil surface.
Interestingly, these changes were associated with a decrease in the rapidly exiting subpopulation of cells born on E14.5 (Takahashi et al., 1996a).
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