Sentence examples for rapidly evolving severe from inspiring English sources

The first two drugs constitute first-line treatments, but fingolimod is licensed by the European Medicines Agency for RRMS patients with highly active or rapidly evolving severe RRMS, as described in the Summary of Product Characteristics [11].

Don't get me wrong, there is very useful information that help plan your week or perhaps day....all Apps are not created equal and should not be painted with the same broad stroke....However, it is important to understand the limitations of Apps in rapidly evolving severe weather, snow, or hazardous weather.

In the case of breakthrough disease on first-line therapy, or rapidly evolving severe RRMS, second-line therapy with natalizumab, fingolimod or alemtuzumab should be chosen based on careful risk−benefit stratification.

It is approved in the USA for treating patients with relapsing forms of MS [ 23], and in the EU either as first-line therapy in patients with rapidly evolving severe RRMS or as second-line treatment in patients with RRMS and high disease activity despite treatment with at least one DMT [ 24].

Natalizumab (Tysabri®, Biogen Idec) is a humanized anti-α4 integrin mAb approved in the USA for the treatment of relapsing forms of MS and in the EU for the treatment of rapidly evolving severe RRMS and highly active RRMS among patients with disease breakthrough on IFN beta or GA [ 47, 48].

After an incubation period of 3 to 7 days, the patient has sudden onset of fever, chills, myalgia, headache, and rapidly evolving severe illness, followed by a hemorrhagic state with bleeding from the mucous membranes and petechiae, associated with thrombocytopenia and leukopenia (10 ).

The rapidly evolving pleuropneumonia may in severe cases lead to death within 24 36 hours, likely due to the combined effect of tissue damage caused by the bacteria, and a strong proinflammatory immune response [ 15, 17].

More severe and rapidly evolving hyponatremia can lead to seizure, coma, or even respiratory arrest [10].

A 71-year-old man presented with a rapidly evolving swelling of his left thigh and severe pain.

A 71-year-old man presented with rapidly evolving swelling of his left thigh and severe pain.

In this article, we discuss the rapidly evolving area of direct-to-consumer genetic testing and the current utility of clinical exome sequencing, especially in very early onset, severe IBD cases.