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In vivo, the conjugate rapidly distributes and is cleared by the kidney.
γ-Camera imaging demonstrated that In proteins remained in the tumour for at least 72 h, whereas unbound InCl3 rapidly distributes throughout the mice.
Following 1-h intravenous infusion, AT7519 rapidly distributes and its elimination follows first-order kinetics with a mean t1/2 of 13.1±4.0 h.
Fortunately, at the doses administered, luciferin does not appear to be toxic to animals and rapidly distributes throughout the mouse (Contag et al., 1997), crossing the blood brain and placental barriers (Lipshutz et al., 2001; Rehemtulla et al., 2002;).
Except for a brief mention by Schloerb et al. (1950), we are not aware of any study discussing that, after ingestion of water labeled with D2O, plasma D/H can follow two different patterns and that in some subjects the water ingested rapidly distributes in a central compartment before diffusing with a small delay in the entire BWP.
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The drug was rapidly distributed with half-life of distribution t1/2α of 0.24 ± 0.01 h and moderately eliminated with elimination rate constant and elimination half-life of 0.27 ± 0.13 h−1 and 2.57 ± 0.52 h, respectively.
After single intravenous administration, XR11576 rapidly distributed from plasma into the tissues, resulting in a large volume of distribution.
However, pharmacokinetics of BTZ are well known as the drug has been shown to be rapidly distributed into tissues after administration of a single dose, with an initial plasma distribution half-life of less than 10 minutes.
Food, water, electricity, medicine, and other resources will need to be rapidly distributed.
The images were rapidly distributed and got more than 500 "likes" before they were removed by Twitter.
The second was that the internet meant that any banned visual material was rapidly distributed without control and so it was preferable to have a controlled official release.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com