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Fish retina and tectum, and fly optic lobe, develop from a partitioned, unidirectionally proliferating neurectodermal domain that combines slowly dividing neuroepithelial stem cells and rapidly amplifying progenitors with shared genetic signatures to generate large numbers and different types of neurons in a temporally ordered way.
Overall, differential expression of TgAP2 is not extensive between tachyzoite and merozoites, and this may reflect their similar life cycle fate as rapidly amplifying asexual stages.
TA cell undergoes a limited number of rapidly amplifying cell division cycles to increase the cell population derived from a single PSC before leaving the proliferative compartment to produce intermediate cell [ 106].
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So when the winning VFX team's speech mentioning this was overdubbed by the rapidly-amplifying theme from Jaws, it made their shout-out seem censored for content rather than time-pressure.
The progeny of type B cells are rapidly dividing transient amplifying cells (type C cells).
They divide slowly to generate rapidly dividing transit amplifying cells, which in turn give rise to neuroblasts.
11, 12 CSC are generally quiescent, but can give rise to rapidly dividing transient amplifying cells, which form the bulk of tumor cells (Fig. 1).
Proliferation in most continuously renewing tissues is hierarchically organised, with a small number of infrequently dividing pluripotent stem cells and a larger number of rapidly dividing 'transit amplifying' cells with more limited developmental potential [ 1].
13 Wnt target genes were chosen and subdivided into the categories defined by Van der Flier et al: 22 genes expressed in the rapidly dividing transit amplifying cells (Axin2, EphB2, CyclinD1, Lef1) genes expressed by post-mitotic Paneth cells (EphB3, Mmp7 (mouse only)) genes expressed in the stem-cell position of the crypt (Lgr5, Olfm4 and Ascl2 (mouse only), Sox4 (mouse only)).
However NSC activation at the earlier time-point was maximal, as shown by comparing the level of activation after ischaemia with that seen when they efficiently and rapidly regenerate the amplifying precursor population niche after ablation of the latter population with AraC.
To study the rapidly dividing transit-amplifying progenitor cells (type C cells) we used short-term IddU labelling protocols (see Supplementary data).
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