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We previously found that there was a rapid stimulatory effect of acute (1 day) 'binge' cocaine on CRH mRNA levels in the rat hypothalamus.
To determine which ER subtype was responsible for mediating the rapid stimulatory effect of E2 on [Ca2+]i oscillations, the cells were treated with ERα or ERβ-selective agonists.
Mitiglinide shows rapid stimulatory effect on insulin secretion and reduces postprandial plasma glucose levels in type 2 diabetes patients [ 73- 75].
It has a rapid stimulatory effect on insulin secretion and reduces postprandial plasma glucose level in patients with type 2 diabetes.
These findings are consistent with the rapid stimulatory effect of DHEA on basal glucose uptake observed in this study, which suggests that DHEA is acting via a nongenomic mechanism.
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We hypothesize that the pool of active SFKs in resting platelets is to maintain essential constitutive biologic processes and to initiate a rapid response to a stimulatory signal.
Thus, the proarrhythmic effect of estrogenic chemicals in female rodent hearts was dominated by the stimulatory ERβ rapid signaling, whereas in male hearts the effect of ERβ was present but masked by the inhibitory ERα signaling, resulting in a lack of observable response.
Moreover, recovery to baseline was relatively rapid because of an efficient stimulatory effect of G-CSF on neutrophil production in the partially recovered BM.
Binding of a naïve T cell's TCR to a structurally compatible pMHC on an antigen-presenting cell will, with the appropriate interaction of co-stimulatory molecules, initiate rapid clonal expansion to generate a population of effector cells carrying identical TCRs.
Wild type and TLR4-deficient mice were then inoculated with B. parapertussis and purified LPS from B. bronchiseptica, E. coli, or B. parapertussis to determine if the addition of TLR4 stimulatory LPS was the key to rapid clearance of B. parapertussis.
It has been previously suggested that, with nitric oxide as a key mediator, sepsis elicits a very reproducible pattern of pituitary hormone secretion, with plasma ACTH and prolactin increasing within a few minutes following the insult and with a rapid inhibition of secretion of luteinizing and thyroid-stimulatory hormone [ 2].
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