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GCMS is a suitable instrumental to detective metabolites, which provides a rapid, steady, and high-throughput methodology.
In our method, we assume that some of the complexes attain rapid steady states and hence we equate the rates of inflows to and outflows from such complexes.
This hypothesis requires a rapid steady state HSC turnover between marrow and other tissues and may explain the high HSC numbers observed in the blood within 30 minutes after plerixafor administration [ 23].
This shows that in this case, our model reduction approach will perform differently from a time-scale separation technique where metabolites with faster convergence times are assumed to attain rapid steady state.
On the other hand, in the case of QSSA, it is rather some of the individual metabolites that are assumed to attain rapid steady states and hence the rates of inflows to and outflows from such metabolites are equated.
When 100× IC50 GNF-Pf4492 or KAF246 was added, a rapid, steady, and comparable increase in intracellular sodium concentration ([Na+] i ) was observed over a 30 min period and this response was demonstrated to be dose-dependent in the presence of GNF-Pf4492.
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Hinkelmann et al. introduced ADAM (Analysis of Discrete Models of biological systems using computer Algebra) [ 28], a web-based tool for rapid steady-state identification in various discrete model types.
After that, though, stocks began a rapid and steady descent.
Throughout the 1890's, though they were a time of economic misery for many, the westward migration was, in the words of demographic historian Walter Nugent, "not rapid, but steady and endemic".
According to the indictment issued yesterday, in the month afterward a rapid and steady infusion of money and men began and culminated 16 months later in the Pentagon and the World Trade Center attacks.
Confusion and disagreement about the DNP degree and its implications continues despite the rapid and steady growth of DNP programs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com