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Design of specific and sensitive imaging probes for targeting tumor microenvironment holds great promise to achieve precise detection and rapid responsiveness to neoplastic tissues.
Aquaporin 8 messenger RNA demonstrates a relatively short biologic half-life in vitro, which renders its rapid responsiveness to regulation (Am J Obstet Gynecol 2003 188 997-1001).
Fasting insulin concentrations can be highly variable because of serum half-life, cyclicity, and rapid responsiveness to hormonal and metabolic milieu (21).
A critical point is that the inherent noise from the firing of neural populations acts first to allow a state of rapid responsiveness to inputs.
Consequently, stem cell self-renewal and rapid responsiveness to differentiation cues can simultaneously reside in a single stem cell population in which individual cells experience the same environmental stimuli.
The presence of different clinical features common to both PMR and GCA (e.g., older age at onset with progressively increasing incidence rates after 50 years, similar sex ratio, substantial increase of acute-phase reactants, and rapid responsiveness to glucocorticoids) has suggested that they might be different manifestations of the same underlying process [ 1].
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The rapid responsiveness of these genes to growth factor stimulation is due to serum response elements (SREs) in the promoters of these genes [15].
Broadly expressed by epithelial cells, phagocytic, and antigen- presenting cells, TLRs are critical sensors for innate immune defenses, allowing rapid detection and responsiveness to elements expressed by a wide range of microbes.
Such services would also need to scale out, yet must maintain their rapid responsiveness and strong consistency.
Furthermore, the sensitivity and rapid responsiveness of the system permit biomarker monitoring with both high spatial and temporal resolution.
These redox sensors have large dynamic range, rapid responsiveness, a flexible "switch", and pH-independence, are particularly compatible with hypoxia conditions, and therefore represent a substantial improvement for live-cell redox measurement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com