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The slow cell cycle may provide cancer stem cells a protective mechanism against certain therapeutic approaches that target rapid proliferating cells.
Several studies reported recently that rapid proliferating tumors have a higher response rate to chemotherapy [ 19, 20].
These cells are capable of rapid proliferating to effector cells in response to stimulation of specific antigens.
Intratumoral hypoxia is a result from the poor vasculature formed in the rapid proliferating cancer leading to the development of a microenvironment with low oxygen environment.
It is thus tempting to speculate that HAL2 may also be critical for the rapid proliferating of the adult intestinal stem cells during metamorphosis by initiating histidine catabolism.
Specific cell cycle arrest of rapid proliferating epithelial stem cells is a promising approach to protect the mucosa from the direct side effects of anti-cancer treatment.
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The normal cell regulation and during disease conditions the importance of signaling has been recognized, [ 72, 73] and many well-known targets at the signaling levels have been identified that are critical rapid proliferate of cancer cells.
Rapid proliferation was a unique feature of DN αβT cells in the gut epithelium as less than 5% of SP αβT cells proliferating in the 24-h period.
CTL responses exerting strong selective pressure emerged early and led to rapid escape, proliferated rapidly and were predominant during acute/early infection.
As shown in Figure 5B, HU treatment led to the rapid removal of proliferating cell nuclear antigen (PCNA) from stalled replication forks, while triggering H2A.X phosphorylation as a consequence of checkpoint activation (Sirbu et al., 2011).
Moreover, because the homotetrameric architecture of Kinesin-5 appears to be required for MT MT crosslinking and for normal mitosis and cell division (Hildebrandt et al., 2006; Tao et al., 2006), it is plausible to think that the disruption of its bipolar, oligomeric state could inhibit the rapid divisions of proliferating cancer cells, thereby providing a strategy for cancer therapy (Owens, 2013).
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