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Positron emission tomography of the CGRP antagonist telcagepant showed a rapid permeation of the blood brain barrier and complete CGRP receptor occupancy at high concentrations.
A transport mechanism adjustment is suspected with PTMSP because of a slightly more rapid permeation rate decrease than indicated by the model.
In contrast to conventional modes of administration, rapid permeation of active molecules through brain capillaries is the most significant barrier to effective drug distribution in the brain.
The potential of functional mechanotransduction channels were examined using FM1-43FX dye, which is used to identify the onset of transduction channel function by virtue of rapid permeation in developing HCs.
Therefore, the internalization characteristics of the scFv3G1 were sufficient for the intracellular delivery of therapeutic agents, which thus may be released to the endolysosomal compartment, followed by rapid permeation into the cytosol and nucleus.
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The pores and pore connectivity in concrete cause rapid water permeation.
The BN network also displayed hydrophobicity with water contact angle of 136.9° and oleophilicity with rapid oil permeation.
In summary, we have proposed a novel 3D all-carbon NF membrane with tremendous properties, namely, ultrathin nanosheets with high adsorption, stabilization with extraordinary anti-fouling properties, and rapid water permeation.
Plating thin Pd or Pd-Ag alloy film on the outer surface of a porous alumina ceramic tube enables very rapid hydrogen permeation with an absolute selectivity based on the solution-diffusion transport mechanism.
Rapid sodium permeation was observed exclusively from the extracellular milieu, and following similar binding pathways in all three ligand-free OR systems, notwithstanding extra densities of sodium observed near nonconserved residues of κ-OR and δ-OR, but not in μ-OR.
In tumor tissues, submicron-sized defects exist on the vascular wall because of rapid angiogenesis, enabling the permeation of macromolecules through the wall.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com