Sentence examples for rapid off from inspiring English sources
The PK/PD analysis suggested that moderate affinity and rapid off rate of GSK315234 may lead to a U-shape dose response.
One potential explanation for this data is moderate to poor binding affinity (800 pM) and rapid off rate of GSK315234 compared to the higher affinity OSM receptor (150 pM) causing a protein carrier effect.
[ 9]Considering the role of IL-1 as a functional cytokine in host defense against infection, once eliminated by antibiotics, infection and its accompanying inflammation are no longer present and the "on" signal for cytokine production becomes a rapid "off".
In this world of routine crises, Tommy Lee Jones, with his odd, rapid, off-center delivery, was perfectly at home.
Results also indicated that the presence of high-surface-area water aeration media shielded biofilms from complete disinfection, resulting in less and slower off-flavor removal from Atlantic salmon filets; while depuration systems void of media resulted in greater and more rapid off-flavor reduction.
The rapid off-rate of H1 in cytoplasm is likely connected with our observation that the intensity of somatic H1 on chromatin is only ∼10% of that in buffer.
The affinity of a single receptor for HpHb is modest, at ∼1 μM, with a rapid off-rate.
It has recently been shown that ixazomib/MLN9708, an oral analog of bortezomib that is undergoing clinical evaluation, has a much more rapid off-rate from β5.
Thus, highly stable variants elicited similar or enhanced competitive T4 responses, whereas variant epitopes with rapid off-rates from H-2Kb showed diminishing competitive responses, culminating in a reversal of the immunodominance hierarchy with epitope F5Y, C8G (Fig. 4).
One potential explanation is for a protein carrier effect due to the moderate to poor binding affinity (2.14 nM at 37°C by BiaCore) and rapid off-rate (1.73× 10) of GSK315234 compared to the higher affinity OSM receptor (150 pM) at the site of action in the synovial joint.
An exploratory analysis of clinical, pharmacokinetic and pharmacodynamics data suggests the lack of efficacy may be due to moderate binding affinity and rapid off-rate of GSK315234 as compared to the higher affinity OSM receptor causing a protein carrier effect prolonging the half life of OSM due to accumulation of the OSM/antibody complex in the serum and synovial fluid.
