Third, the evolution of leukemia is rapid, supporting the notion that it occurs without the requirement for additional genetic events.
Insights from the study of complex systems, particularly the chaos theory, point to one of the most fundamental limitations of sustainability, namely, the ubiquity of change, whether gradual or rapid, and the notion that states of equilibrium are the exception and that, even when they exist, they are only temporary with regular transitions between multiple equilibria.
This notion of rapid economic change has been popular for at least five years, roughly since Netscape Communications went public amid great acclaim and the Internet became recognized as a mass medium.
These results support the notion that rapid extrusion of intracellular Mg2+ is mediated by SLC41A1 and provide the evidence that the intracellular free Ca2+ concentration is influenced by extrusion of intracellular Mg2+ which facilitates fibrosis reaction in cardiac fibroblasts.
Our results support the notion that rapid folding of the hydrophobic core with concomitant incorporation of strand 1C into β-sheet C traps the serpin molecule into its native metastable conformation.
This is a surprising result but not necessarily inconsistent with the notion of rapid urban growth at the coast.
This is non ideal and runs contrary to the notion of rapid elasticity and simple horizontal scaling.
Corroborating this notion of rapid synthesis, the amino acids found in the Murchison meteorite were apparently formed in less than 105 years (Peltzer et al. 1984).
The same pattern of gradual assembly can be demonstrated for the emergence of teleosts from their actinopterygian relatives (Donoghue and Purnell 2005), dispelling any notion of rapid organismal evolution or an explosive radiation (Wagner et al. 2003).
These results are in agreement with the emerging notion that rapid protein synthesis in axons and growth cones regulates growth cone behavior [see [27] for a recent review].
Several findings support the notion that rapid estrogen signaling is mediated by ER associated with specialized lipid raft domains that serve to concentrate and provide a matrix for receptors and related signaling proteins [40], [41].
