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The daily measurements showed that population doubling time did not change substantially during the first 150 divisions, and then showed a rapid, marked decrease.
A sudden Ca2+ load produced uniform dehydration of the RBCs, seen as a rapid, marked, and largely parallel left shift in the osmotic fragility curve; after 10 minutes, the RBCs have attained near-maximal dehydration.
At the recommended dose of temozolomide on Schedule A, 150 mg m−2 day−1 × 7 days every 2 weeks, peak plasma temozolomide concentrations and AUC0− t values would be expected to approach maximally tolerated values, and AGAT inactivation is rapid, marked, and sustained.
Three goats vaccinated at CIRAD with a batch of the reference vaccine displayed rapid marked seroconversion, which was detectable after as little as one week.
Similarly, agalsidase beta 1 mg/kg/2 weeks resulted in stabilization of the GFR with rapid, marked, reductions in plasma and tissue Gb3 observed by biochemical and histological means [ 61].
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The Atures Rapids mark the beginning of the lower Orinoco basin, in which the river makes its great bend to the east.
We bobbed and weaved upstream and slowly picked up some proficiency as we angled towards Difficult Run Rapids, marking the end of the gorge.
In the case of the Holkars, the rise in status and wealth was particularly rapid and marked.
In contrast, a rapid and marked [Ca2+]i rise was observed in WT cells (Fig. 5A).
The environmental conditions associated with such phases, and the rapid and marked transitions between them, likely affected the distributions and adaptations of human populations.
PP seems to have a more rapid and marked effect than KT.
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