Exact(11)
The rapid lethality that occurs in Fischer rats following intravenous injection of LT provides an assay that is widely used in the evaluation of LF-directed therapeutics.
Recently, we observed that C57BL/6 mice are susceptible to V. cholerae infection resulting in rapid lethality in a dose-dependent manner [6].
Shortage in thymine entails rapid lethality in living cells [ 12, 18].
This resistance was remarkable since S180-induced malignancy with rapid lethality has not been effectively treated previously by any other existing therapy.
This non-specific disruption of multiple miRNAs led to pericardial oedema, poorly developed ventricular myocardium and rapid lethality in mouse models.
Gene essentiality as determined by laboratory mutagenesis are dependent on experimental contexts, and only identifies genes whose inactivation results in rapid lethality or high-fitness cost under the tested conditions.
Similar(49)
Genetic studies in this area are complicated by the fact that adam17 total knockout leads to rapid postnatal lethality (Horiuchi et al, 2007; Peschon et al, 1998).
However, there was no corresponding increase to detectable VSG in these cells, probably due to the rapid onset of lethality.
It is also interesting to note that the Manchurian pneumonic plague epidemic (human-to-human versus the vector-borne transmission route of exposure which occurs in the bubonic variant) experiences a rapid decline in lethality as seasonal temperatures warm.
One explanation for the rapid decline of the lethality of the disease is that doctors simply got better at preventing and treating the pneumonia that developed after the victims had contracted the virus, although John Barry stated in his book that researchers have found no evidence to support this.
In the commonly accepted paradigm, rapid S. aureus-associated lethality in MyD88-knockout mice is a predictable consequence of a handicapped, immunodeficient peripheral immune system.
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