As we found that sAPPα-induced a rapid upregulation followed by a generalised downregulation of gene expression, we hypothesised that this temporal pattern may be regulated by microRNA.
The pattern of the psoriatic adverse events do not match the short time to onset and rapid spontaneous resolution of acute generalised exanthaematous pustulosis 14 35 and biopsies of selected cases have confirmed typical histological features of psoriasis.
The population and comparative analyses of centromere DNA sequences presented here lead to the conclusion that rapid centromere evolution is caused by a generalised increase in the mutation rate and not by meiotic drive or recombination.
Sluimer et al 21 identified that more generalised whole-brain atrophy may reflect rapid disease progression in comparison with more localised hippocampal atrophy in slow progressing AD; Karas et al 22 suggested the precuneus as a marker for progression of early-onset AD.
Results cannot necessarily be generalised to nations or cultures undergoing more rapid changes and further research is required in these settings.
There were good reasons to expect the overshoot to be temporary, he argued, since there was not "a generalised rise in prices and wages caused by rapid growth in the amount of money spent in the economy".
Evidence presented here suggests that rapid centromere evolution in S. cerevisiae is due to a generalised increase in the mutation rate and not due to recombination or meiotic drive.
In summary, it appears that a generalised increase in the mutation rate is responsible for the rapid evolution seen at point centromeres, and this is not the result of gene conversion as recently proposed [ 10].
Furthermore, these results suggest that rapid centromere evolution does not result from the mutagenic effect of gene conversion, but from a generalised increase in the mutation rate, perhaps arising from the unusual chromatin structure at centromeres in yeast and other eukaryotes.
Compared with the slow, generalised atrophy of uncertain causation which characterises intrinsic skin ageing, extrinsically aged skin is characterised by a rapid and differential remodelling of diverse ECM components which is thought to be driven primarily by cellular responses to UVR [5, 47].
