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It is believed that a combination of these technologies can effectively solve problems associated with the rapid fixation of implants into tissues.
Our approach uses rapid fixation of cells using 10% trichloroacetic acid, which immediately prevents post-lytic oxidation.
This was due to the so-called 'strong selection, weak mutation' assumption, that is, that adaptation occurs through emergence and rapid fixation of single mutations.
However, it is unclear whether these selective forces would act to preserve existing diversity, promote novel diversity, or reduce linked neutral diversity during rapid fixation of advantageous alleles.
This complex model of 'multiallelic' directional selection seems to better fit the patterns of NAT2 diversity observed in present-day populations than the standard 'hard sweep' model which assumes the rapid fixation of a single newly arisen advantageous mutation [10].
Further, high male reproductive variance enabled by promiscuity and infidelity of both sexes, irrespective of social monogamy, may be essential for the rapid fixation of beneficial genes within a population.
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In fish, the conventional technique for induced androgenesis has been applied for rapid fixation to traits, recovery of cryopreserved genotypes, sex-control, etc.
Such observations imply that upon a dramatic change in the environment that promotes speciation, rapid fixation rate of duplicated toxin genes occurs so as to allow the introduction of novel toxic phenotypes.
This last mutational type is typically highly advantageous in the presence of antibiotics, leading to rapid fixation, often within hundreds of generations [ 17].
This rapid fixation may reflect the presence of emergent support, a situation in which the accumulation of nodal support is more rapid than would be predicted based on the levels of support on individual gene trees (Gatesy et al. 1999; Gatesy and Baker 2005).
Several of the nodes on the T3 tree achieve rapid fixation during the concatenation process despite a substantial amount of incongruence among individual genes (fig. 3).
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