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Zhan et al. [ 41] reported increased transcript levels of antioxidant genes SOD1, CTT1 and GSH1 in a rapid downshift in the growth temperature of S. cerevisiae from 30°C to 10°C.
On the other hand, it was also found that the Sln1 branch of the HOG pathway is activated when membrane fluidity is reduced by a rapid downshift in temperature to <10° or by dimethyl sulfoxide treatment (Hayashi and Maeda 2006; Panadero et al. 2006).
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They move with each other, of course, but it also looks as though the steady downshift in NGDP growth from the 1990s to the 2000s to the 2010s is matched by a downshift in employment growth.
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