Sentence examples for rapid component of the from inspiring English sources

The IKr channel produces the rapid component of the delayed rectifier potassium current IKr which is involved in repolarization.

In fact, most drugs that prolong the QTc interval have been shown to block cardiac potassium channels, especially the rapid component of the delayed rectifier [ 21, 22].

Drug-induced prolonged QT intervals in humans are usually caused by the drug's ability to inhibit IKr, the rapid component of the delayed rectifier potassium current.

Activation of the rapid component of the delayed rectifier potassium current, IKr, terminates the plateau phase and initiates repolarization of the cardiac action potential.

These experiments suggest that feedback inhibition to the rod bipolar terminal accounts for the majority of the rapid component of the overshoot.

Removal of this larger rapid component of the response by Zn2+ inhibition revealed the presence of a smaller, later and more prolonged response that reached a peak 15 s after agonist application (Fig. 7D).

Although the rapid component of this feedback is widely considered to contribute to regulation of dynamic HPA activity, few in vivo data exist on the temporal and pharmacological characteristics of this phenomenon.

The Kv1.5 channel, a member of the superfamily of voltage-dependent K+ channels (Kv; channel nomenclature follows Alexander et al., 2009), carries the ultra-rapid component of the delayed-rectifier K+ channel current (IKur) in cardiomyocytes (Nattel et al., 1999).

An additional observation made from the AP simulations is that incorporation of IANION also influenced the profile of L-type calcium current (ICa,L) during the AP plateau: the initial rapid component of ICa,L was unaffected by IANION incorporation, but the sustained component during the AP plateau showed a modest reduction.

The rapid component of excess postexercise oxygen consumption (EPOC) is thought to reflect the oxygen cost of PCr resynthesis, 36 hence the increased EPOC after hypoxic training may indicate increased PCr turnover during the sprints.

We examined the rapid component of negative feedback using a protocol of injecting methylprednisolone that has been shown to cause suppression of basal HPA activity and blunting of response to noise stress (37, 38).