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To test the hypothesis that a constricted life space, the extent of movement through the environment covered during daily functioning, is associated with increased risk of incident Alzheimer disease (AD), increased risk of mild cognitive impairment (MCI), and more rapid cognitive decline in older adults.
A few dementing illnesses are characterized by rapid cognitive decline and early emergence of neurologic signs.
Like depression, the emergence of psychotic symptoms predicts greater or more rapid cognitive decline [ 44, 95].
Poor physical performance among older adults may also lead to more rapid cognitive decline and early onset of dementia.
A man with a dramatic picture of AD had presented with very rapid cognitive decline, despite being treated with memantine.
Both conventional antipsychotics and just the presence of psychosis have been associated with more rapid cognitive decline in dementia patients (Schneider, Dagerman et al 2006).
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Progesterone supplementation has been linked to more rapid age-related cognitive decline in post-menopausal women [ 71, 72].
Being the most severe form of X-ALD, patients suffer from rapid cognitive and neurological decline and within few years proceed to a vegetative state.
In contrast, CALD usually only affects males and presents with rapidly progressive inflammatory demyelination in the brain, leading to rapid cognitive and neurological decline.
The administration of psychotropic medication has also been associated with a more rapid cognitive and functional decline, and not necessarily with improved NPS [ 15].
The development of BPSD is associated with a more rapid rate of cognitive decline, greater impairment in activities of daily living, and diminished quality of life (QOL).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com