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We describe newly established guidance for guideline developers at the World Health Organization (WHO) on the process and procedures for developing a rapid advice guideline in the context of a public health emergency (e.g., the 2014 Ebola epidemic).
WHO, 2010 [link] / Rapid advice: use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants.
More recently, however, the WHO rapid advice guideline panel for the pharmacological management of human infection with avian influenza A (H5N1) virus applied GRADE successfully [ 30] and several WHO guidelines are under development using GRADE (Sue Hill, personal communication).
We referred to previous experience reported in two World Health Organization (WHO) publications on rapid advice guidelines that made use of GRADE methodology and to Cochrane guideline for public health interventions [ 14, 15, 23].
In this regard, WHO publication on rapid advice guideline that met similar time constraints was a particularly useful reference in helping us to ensure transparency of the process [ 14].
These recommendations highlight that the overall risk of mother to child transmission of HIV can be reduced to less than 5% in breastfeeding populations (from a background risk of around 35%) and to less than 2% in non-breastfeeding populations (from a background risk of around 25%) (WHO 2010, Rapid Advice on PMTCT version 2).
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