Sentence examples for ranking variant from inspiring English sources

In a patient with acute myeloid leukaemia, an S451F amino acid change in the FLT3 gene was the top ranking variant, which has been previously characterized and catalogued in COSMIC (Forbes et al., 2011).

Ranking variants based on association strength (similar to top k) and this probabilistic approach (Maller et al., 2012) assuming a single causal variant give identical relative rankings.

The final choice of the restoration strategy for the out-of-service area is made by the operator on the basis of the list of ranked variants.

However, the two commonly used measures of genetic association, the odds-ratio (OR) and p-value may rank variants in different order.

PriVar (Zhang et al., 2013) combines variant pathogenicity scores from multiple sources together with pedigree information to rank variants.

The second type, composed of a large number of distantly associated equally ranked variants was typical for sustained responders.

A common approach is to calculate marginal association statistics for each variant and, depending on the study budget, select the top K ranked variants for follow-up studies.

Consequently, p values have been used to rank variants across a locus in terms of their likely causal impact on T2D susceptibility.

The SNVs/indels are characterized using several genomic or functional annotations that VaRank summarizes into a score to produce a list of ranked variants (manuscript in preparation).

MIP performs the bioinformatics analysis from raw sequences to biologically relevant, annotated and ranked variants for the final pulse in approximately 4 hours.

Here we describe the algorithm we developed to select participants with the greatest potential for actionable variants (the "selection algorithm,") and the algorithm we developed to rank variants with highest impact (the "ranking algorithm").