The rank of severity in the table is based on the definition given in Section 3.3.
The GAP-derived rank of severity also provided us with a unique way, where expression of most relevant genes were all considered, to decipher the meaning of the changes in other genes obtained from the same microarray experiment.
To identify genes that selectively regulate hypoxic sensitivity, we compared the whole-organismal transcriptomes of three daf-2 reduction-of-function alleles, all of which are hypoxia resistant, thermotolerant, and long lived, but differ in their rank of severities for these phenotypes.
The organization also raised its official level of influenza preparedness a notch, the first time it has done so since it adopted its current ranking of influenza severity in 1999.
Notably, the ranking of the severity of pathology for each mutation across different tissues was not consistent suggesting that there may also be tissue-specific differences in expressivity.
While there is a high level of agreement among the instruments in their ranking of the severity of complications, it would appear that those algorithms based on the EQ-5D produce greater mean differences for macro vascular complications such as stroke, as might be clinically expected.
In order to use the injury group as a model input, all the sheep were modeled independent of group and a rank order of severity was determined.
The rank order of allele strength for longevity at 22.5°C and 25°C is e1370 < m41 < m596 (our data not shown; [ 3]), but daf-2 alleles have a variety of phenotypic effects which do not all show the same rank order of severity [ 3, 34, 39].
Functional effects of variants can be classified into 34 consequences in Sequence Ontology [ 41], which were ranked in the order of severity (more severe to less severe) by Ensembl analysis group [ 40, 42].
