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In BRCA, although some known drivers such as TP53 and ATM were detected by multiple methods, DawnRank detected important known driver genes in the top 10 such as CDH1 and PIK3R1, and BRCA1 in breast cancer which were not detected by either PARADIGM-Shift or DriverNet as top ranking drivers.
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In summary, integrating protein interaction data with the transcriptional network almost always increased the power to rank drivers, as compared to the transcriptional network alone.
We then ranked the drivers (by number of emerging and reemerging pathogen species associated with each) and compared the ranking of drivers for the major pathogen groups and for zoonotic versus nonzoonotic pathogens.
In the first focus group meeting, participants identified and ranked sanitation drivers in their community.
Moreover we can improve our ability to rank phenotypic drivers by combining the information from individual networks.
Five of the six Jones et al.-ranked driver candidate genes (TP53, CDKN2A, KRAS, TGFBR2, SMAD4) were represented in the top 500 MeSHOP predictions; MeSHOP comparisons did not identify the sixth gene, MLL3.
According to an Allstate survey in 2011, drivers rank themselves well above other drivers on the road, in terms of driver knowledge, ability, and safety.
DawnRank ranks potential driver genes based on their impact on the overall differential expression of its downstream genes in the molecular interaction network.
The ranking of drivers across different categories of pathogen showed poor concordance (e.g., Spearman rank correlation for bacteria vs. viruses, r s = 0.41, n = 10, p = 0.24).
The trouble starts with the fact that the ranking methodology Car and Driver used was essentially the same one it uses for all the vehicles it tests — from S.U.V.s to economy sedans.
The trouble starts with the fact that the ranking methodology Car and Driver used was essentially the same one it uses for all the vehicles it tests from S.U.V.s to economy sedans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com