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Rank Terms: Assess the enrichment of gene sets on Gene Ontology terms 24.
The combined score (log (p value) ∗ Z-score) serves to rank terms, taking into account both approaches [ 43].
In order to rank terms, we compared each terms score (by either method) to a distribution of scores between the same term and randomly selected gene sets.
Our set of programs includes the Rank Terms tool (#27) to determine the enrichment of a gene list (i.e., mutated genes) in GO terms.
In support of these results, the Rank Terms tool (#27) produced a list of GO terms related to ECM-receptor interaction that were significantly enriched in the genes with non-synonymous mutations above LSBL95.
In rank terms, for a PCT, an improvement of 8.8% between 2011 and 2012 would have resulted in that PCT being the fourth most improved PCT in the UK (displacing Torbay that achieved an 8.2% improvement).
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Additionally, respiratory failure is a more appropriate highest rank term than hypertension.
A reduced rank term-by-gene matrix was generated by computing the singular value decomposition (SVD) as described previously [15].
The unification problem presented by us generalizes some known problems, such as, e.g., order-sorted unification for ranked terms, sequence unification, and word unification with regular constraints.
Such content identification and representation is done by displaying only the selected number of the highest TFiDF ranked terms from a BoW vector constructed for a selected community.
The 20 highest ranked terms appear in Appendix A (included in Supporting Information S1).
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