For this reason, it is better to limit the time range of map pairs included in (5) (or, as an alternative, it is also possible to penalize the terms in the sum as a function of the delay between maps).
We assessed PWV over a wide range of MAP using phenylephrine and nitroglycerine to raise and lower MAP, respectively.
In healthy conditions RBF is stable within a wide range of MAP, due to regional autoregulation [ 13].
In our model, sepsis at an early phase did not impact RBF over a large range of MAP.
The diabetic rats had a significantly higher PWV compared to the control rats across a supraphysiological range of MAP (170 200 mmHg), but not at a lower MAP range.
This observation could indicate that the slope of the MAP/RBF relationship may be similar across all groups in this range of MAP.
PWV was plotted against MAP at 5 mmHg increments to characterise PWV over a wide range of MAP from 50 to 200 mmHg.
The principal finding of this study was that diabetes was associated with differential effects on the aortic stiffness, demonstrated by higher isobaric PWV at a supraphysiological range of MAP (170 200 mmHg), but not at a lower MAP range.
The lack of available data supporting a specific MAP target during the initial resuscitation of septic patients is emphasized by the wide range of MAP goals (60 to 100 mmHg) applied in randomized controlled clinical trials [ 16].
Also at the peak, a 1-LOD support interval for estimated QTL position was determined by determining the range of map positions that are within one LOD of the peak.
