A wide range of dosing regimens was covered by different groups of patients.
There was a wide range of dosing regimens: infusion schedules varied 10-fold and loading doses 15-fold.
In studying environmental hazards, one needs to test mixtures of many chemicals, across ranges of doses, at different points in time, and at different ages, from conception to childhood to old age.
Second, over wide ranges of doses there is weak evidence only of dose-responsiveness with these drugs.
The applied approaches used to study the dose response relationship differ between showing average effects for ranges of doses and establishing continuous dose response functions.
ITB also had the added advantage of being reversible and programmable to a wide range of dosing regimens.
So, like other bisphosphonates, risedronate remains active on the surface of bone for long periods after dosing, providing the opportunity to develop a range of dosing schedules.
The reactions, which included serious and sometimes deadly effects like respiratory failure, involved a range of doses and uses, many of them off label.
The drug was only in a Phase I trial — that is, a trial designed to determine the toxicity of a range of doses, not whether the drug worked.
