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For two particular cases of growth and agglomeration including size-dependent nuclei formation, simulation data was generated by continuous feeding of nuclei in a certain range to demonstrate the capability of parameter extraction of the model.
These CVs are in an acceptable range to demonstrate reproducibility of the data used by the classifier to distinguish VTE and non-VTE groups.
Otherwise, it will be necessary to investigate a relevant dose range to demonstrate that the test system is discriminatory.
The swelling behavior of the microgels was assessed in the 2.2 7.4 pH range to demonstrate the pH sensitivity of the hybrid microgels.
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Second, we re-evaluate paleoclimatic records from the Calchaquíes basin (66°W, 26°S), a large intermontane basin bordered by high (> 4.5 km) mountain ranges, to demonstrate temporal variations in erosion rates associated with changing climatic boundary conditions during the late Pleistocene and Holocene.
For both dose groups, 90% CIs were within the predefined range necessary to demonstrate bioequivalence of the two agents.
Ninety percent CIs for ANC Cmax, ANC Cmin, and CD34+ cell counts at day 5 were all within the predefined range required to demonstrate bioequivalence of the two agents.
As with the primary endpoint, 90% CIs for AUC0 tlast, Cmax, and T1/2 were within the predefined range required to demonstrate bioequivalence of the two agents, irrespective of administration route.
Geometric mean area under the curve from time 0 to the last time point (primary endpoint) was similar in volunteers given Hospira filgrastim or Amgen filgrastim following i.v. (ratio of means: 0.96; 90% CI: 0.90 1.02) or s.c. (ratio of means: 1.02; 90% CI: 0.95 1.09) dosing; 90% CIs were within the predefined range necessary to demonstrate bioequivalence.
Geometric mean absolute neutrophil count area under the curve from time 0 to the last time point at day 5 (primary endpoint) was comparable in volunteers given Hospira filgrastim or Amgen filgrastim at 5 µg/kg (ratio of means, 0.98; 90% CI, 0.92 1.05) or 10 µg/kg (ratio, 0.97; 90% CI, 0.93 1.01); 90% CIs were within the predefined range necessary to demonstrate bioequivalence.
After establishing this methods validity, future studies should conduct a 7-day PA collection period to compare time spent in PA intensities between relative and absolute cutpoints in a heterogeneous population (large age and BMI range) to effectively demonstrate the variability that may exist in recorded time spent in MOD- and VIG-PA.
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