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The approach of using very high-dose testing to predict consequences of much lower doses that are typically within the range of widespread human exposure emerges from a 16th-century observation by Paracelsus that toxicologists paraphrase as "the dose makes the poison" (Gallo 1996).
Similar(59)
Range contraction of widespread species may have left isolated populations in marginal areas, providing chances for peripheral speciation of regional endemics [ 2– 5].
Both clades showed widespread ancestral haplotypes with tip haplotypes restricted to single localities within the range of the widespread ancestral haplotypes.
More rarely, the same species was domesticated more than once, in different parts of the range of a widespread wild progenitor.
The occurrence of phylogenetically-nested troglomorphic populations of spring salamanders (genus Gyrinophilus) within the geographic ranges of more widespread surface forms has been invoked as evidence for speciation with gene flow, and thus, supportive of an adaptive-shift hypothesis [ 72].
The range of testing comprises widespread sand core-systems (amin-pur-coldbox and CO2-water-glass) as well as materials less commonly used, namely salt, plastic and zinc.
Heterogeneity in range of dispersal is widespread in nature and the distributions observed are commonly leptokurtic, with a semi-logarithmic curve which approximates to a straight line of negative slope (Bateman 1963).
The use of NaI(Tl) as a detection medium for naturally-abundant levels of 40K in a range of media is widespread, but the use of 40K as a radioactive tracer has not been reported.
The ENFA analysis proved to be an outstanding method to evaluate the factors that limit the distribution range of secretive and widespread species such as V. latastei, updating evaluation of their conservation status.
These syndromes encompass conditions such as fibromyalgia, which manifest with a broad range of symptoms, including widespread pain, fatigue, sleep problems, and cognitive difficulties.
This suggests that the green-headed montane birds represent two separate populations (Usambara Mts, Nguru Mts; Figure 1) nested inside the geographical range of a more widespread lowland, grey-headed, form.
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