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The range of signaling was thus increased to about 2.4 km (1.5 miles), enough to convince Marconi of the potentialities of this new system of communication.
Once cleaved at aa495, the single chain proHGF (inert form) reverts to the active two-chain form of HGF, and mediates a wide range of signaling pathways by binding to the c-Met receptor (Nishida and Hirano, 2003).
By comparing relative bias for MOR-mediated signaling in each pathway, we demonstrate a strong correlation between the respiratory suppression/antinociception therapeutic window in a series of compounds spanning a wide range of signaling bias.
We will discuss how FAK interacts with different extracellular molecules and the cytoskeleton and how FAK functions as a sort of "orchestra conductor" coordinating a broad range of signaling pathways during neuronal motility.
The spectrophotometer-based assay was used to assess the apparent diffusivity D of FITC-dextrans with molecular weight (4 70 kDa) spanning the physiological range of signaling factors in a panel of acellular ECM gels including Matrigel, fibrin and type I collagen.
Our results suggest that Cdc42 affects a wider range of signaling pathways than previously thought.
In contrast, identification of FLT3-ITD signaling outliers was aided by the narrow range of signaling responses observed in this sample set.
In healthy myeloid cells, FLT3L induced a narrow range of signaling with no increases in p-Stat5 (Table S2A, Table 3).
Selection on acoustic communication is likely to favor characteristics that increase the effective range of signaling in the context of mate attraction [34].
CKI family members have been implicated in a wide range of signaling activities including involvement in the Wnt, planar cell polarity (PCP) and circadian rhythms pathways [1] [3].
The SAM domain is a ∼70-residue domain believed to mediate protein interactions in a wide range of signaling molecules [38].
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