Sentence examples for range of prion from inspiring English sources

To explore the possibility that CJD, and not amyloid-β seeds, was the culprit, Collinge and colleagues also examined the brains of 116 people with a range of prion diseases unrelated to the hormone injections.

Hence, we chose a wide range of prion survival values over which to simulate.

We ran simulations over a range of prion survival rates, γ (weekly survival probabilities: 0.9481, 0.9868, 0.9967, 0.9978, 0.9983, translating to half-lives of 0.25, 1, 4, 6, and 8 years, respectively).

PIB scans were negative in three small series featuring a range of prion disorders, including sporadic Creutzfeldt-Jakob disease, variant Creutzfeldt-Jakob disease, and a range of prion protein mutations [ 83, 84].

Moreover, an inverse relationship was observed between the dose of prion inoculum administered and the point of bioluminescence inflection that was observed, relative to mock treated mice, over a wide range of prion dilutions.

These results are interesting as they show that either the range of prion diseases and associated pathology is still wider than previously thought or that substantial abnormalities of prion protein expression may be associated with brain lesions unconnected with classical prion diseases.

PrPSc is detectable in muscle of a wide range of human prion diseases and data from rodent studies show presence of muscular PrPSc in preclinical stages [22], [23], [24], [25].

It follows that an aspect of prion host range may be a species barrier operating at the molecular level that depends on compatibility between the PrPSc from 1 species and the PrPC from another.

In addition, human cases of vCJD have recently emerged in the UK, many years after the eradication of BSE from the country, due to the very long incubation times of prion diseases, which range from months to decades [2].

Observed prevalence was relatively high compared to that previously reported in mule deer populations elsewhere [6], [17], but still within the range predicted by a simple model of prion epidemic dynamics [8].

The candidate gene list for this study was compiled from a diverse range of studies, including linkage to prion disease incubation time in mice, microarray expression and an association with susceptibility to human prion disease.