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Most of them exhibited low micromolar range of potency and very high efficacy.
Modification at the C-3 position of lithocholic acid with a series of acid acyl groups yielded compounds with a range of potency on proteasome inhibition.
This is typically called "release limit" which is a range of potency within which an individual lot can be released to market ensuring that its potency will remain within registered specification limits throughout the shelf life.
In addition, the range of potency values was consistent across the assays, except for the comet assay, which demonstrated higher variability.
Currently, there are eight inhaled corticosteroid molecules approved for clinical use that span a wide range of potency and other attributes.
The wide range of potency was a robust result, but the specific rank order of the samples was different at low and high PM concentration.
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ARN-509, Hydroxyflutamide, Enzalutamide, Nilutamide and Bicalutamide returned reproducible values for intracellular binding affinity to AR spanning a range of potencies (Fig. 3c, Supplementary Fig. S8).
Here we show that, over a 100,000-fold range of potencies, the activity of a pure soluble protein (firefly luciferase) can be inhibited by 50% at anaesthetic concentrations which are essentially identical to those which anaesthetize animals.
The compounds, having a different redox core but the same side chain as idebenone, exhibited a range of potencies, reflecting differences in their structures.
We demonstrate robust inhibitory activity over a range of potencies against the HIV-1 NL4-3 reference strain.
Bile salts, in concentrations of 1 to 5 mmol/L, caused a dose-dependent release of [3H]-glycoproteins with a range of potencies in this order: chenodeoxycholate greater than deoxycholate much greater than cholate greater than ursodeoxycholate = control.
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