For example, in an experiment where the 600 bp multiply mutated fragment was targeted to the genome, across the range of mutations from 20 bp – 300 bp from the marker, the frequency of incorporating mutations decreased almost two-fold in proportion to the distance of the mutation from the marker.
You can tell from the range of mutations you've got in any particular tumour whether the thing will be able to escape treatment.' But what McVie calls 'the ultimate glory' has been the ability to make highly specific drugs aimed at particular cell mutations.
Monovalent binding reduces avidity and potency, thus expanding the range of mutations permitting antibody evasion.
N.C.: With the neuraminidase inhibitors, we don't know the full range of mutations yet that can confer resistance.
In addition to the increased range of mutations that can be targeted, successful multiple exon skipping combinations can then be applied to a broader pool of patients.
As the number and range of mutations detected by clinical NGS assays has increased, it is difficult to apply standard analyte-specific proficiency testing (PT).
A wide range of mutations that switch receptor preference of HA proteins have been identified and include changes throughout the HA gene.
Plasmids are genetically diverse and contain a range of mutations, including both beneficial mutations and neutral (or nearly neutral) mutations that may not confer a selective advantage, but are nonetheless commonly found.
Cases where multiple mutations work collectively to give resistance, while of clear importance, are not well understood, in part because the range of mutations that can increase a particular bacterium's antibiotic tolerance is rarely known.
A range of mutations was observed, including T315I.
That is, these phenomena define the range of mutations, and are part of the writing phenotype.
