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E2 can act directly on a range of lymphocytes including CD4+ T cells, B cells, CD8+ T cells, Macrophages and DC 16, 17, which express both estrogen receptor (ER) isoforms; ER-α and ER-β.
A range of lymphocytes, including natural killer (NK) cells and CD8+ T-cell subsets have been shown to express CD244, which is the high affinity counter-receptor for CD48 (for a review, see [ 49]).
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Accordingly, MST1 deficient animals display a range of lymphocyte associated defects, ranging from defective lymphocyte trafficking to impaired development and function of regulatory T cells (summarised in Table 1).
We wanted to understand the immune response of a broader range of lymphocyte subsets.
The median and range of lymphocyte count of the non-surviving group were slightly lower than those of the surviving group, but the difference did not reach statistical significance.
Following infusion of 6.8 × 106 cells/kglls/kg (range: 0.30-22.3), neutrophil and lymphocyte engraftment occurred in 95% of patients by D +180.
The ASCT, when compared with the subsequent stage of durable virus control and normal ranges of lymphocyte subsets (data not shown), had diminished numbers of B, natural killer (NK), and NKT cells whereas T-cell numbers were overrepresented, consistent with the effects of CSFs prior to the harvest (Table 1) [ 22].
To react to a wide range of antigens, lymphocytes generate a diverse repertoire of antigen-specific receptors that depend on programmed chromosomal rearrangements initiated by enzymes that introduce DNA breaks.
During acute inflammation a wide range of cytokines influence cell activation, cell adhesion and recruitment of leukocytes such as monocytes, lymphocytes and neutrophils.
Limited dynamic range of T lymphocyte activation snapshots at the individual cell level.
We have demonstrated that there is a wide range of CD4+ lymphocyte ATP content in a typical ICU population suffering from sepsis.
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